Gamma-hydroxybutyrate (GHB)-deficiency in alcohol-dependence?

Ameisen O. – Alcohol and Alcoholism. 2007 Sep-Oct;42(5):506. Epub 2007 Aug 1.

I wish to propose a hypothesis that could help explain some of the effects of baclofen in alcohol dependence that are described in Dr. Bucknam’s case study (Bucknam, 2007) and in my self-case report (Ameisen, 2005). At a behavioural level, alcohol, baclofen and GHB all share sedative/hypnotic effects in humans. Clinical trials have shown baclofen to reduce anxiety in alcoholic (Krupitsky et al., 1993; Addolorato et al., 2002) and non-alcoholic (Breslow et al., 1989; Drake et al., 2003) patients alike. …

Gamma-hydroxybutyrate (GHB)-deficiency in alcohol-dependence?

Deficience en GHB dans l’alcoolodépendance

Baclofene, baclofen, alcoolisme, craving, traitement de l’alcoolisme,le dernier verre,Olivier ameisen


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