Dear Editor, The paper by Addolorato et al. (2011) attributes to me and to Dr William Bucknam a hypothesis that neither of us has advanced. Addolorato et al. write: « However, anecdotal reports have hypothesized the ability of high doses of… Lire la suite
Gamma-hydroxybutyrate (GHB)-deficiency in alcohol-dependence?
Ameisen O. – Alcohol and Alcoholism. 2007 Sep-Oct;42(5):506. Epub 2007 Aug 1. I wish to propose a hypothesis that could help explain some of the effects of baclofen in alcohol dependence that are described in Dr. Bucknam’s case study (Bucknam,… Lire la suite
Baclofene – Complete and prolonged suppression of symptoms and consequences of alcohol-dependence using high-dose baclofen: a self-case report of a physician.
Ameisen O. – Alcohol and Alcoholism. 2005 Mar-Apr;40(2):147-50. Epub 2004 Dec 13. AIMS: To test whether the dose-dependent motivation-suppressing effect of baclofen in animals could be transposed to humans, and suppress craving and sustain abstinence. METHODS: Neurologists safely use up… Lire la suite