Baclofen: What’s in a Word? A World of Difference

Dear Editor, The paper by Addolorato et al. (2011) attributes to me and to Dr William Bucknam a hypothesis that neither of us has advanced. Addolorato et al. write: « However, anecdotal reports have hypothesized the ability of high doses of baclofen (up to 140 and 270 mg/day) to reduce alcohol craving and consumption ( Ameisen, 2005a;Read More

Gamma-hydroxybutyrate (GHB)-deficiency in alcohol-dependence?

Ameisen O. – Alcohol and Alcoholism. 2007 Sep-Oct;42(5):506. Epub 2007 Aug 1. I wish to propose a hypothesis that could help explain some of the effects of baclofen in alcohol dependence that are described in Dr. Bucknam’s case study (Bucknam, 2007) and in my self-case report (Ameisen, 2005). At a behavioural level, alcohol, baclofen andRead More

Baclofene – Complete and prolonged suppression of symptoms and consequences of alcohol-dependence using high-dose baclofen: a self-case report of a physician.

Ameisen O. – Alcohol and Alcoholism. 2005 Mar-Apr;40(2):147-50. Epub 2004 Dec 13. AIMS: To test whether the dose-dependent motivation-suppressing effect of baclofen in animals could be transposed to humans, and suppress craving and sustain abstinence. METHODS: Neurologists safely use up to 300 mg/day (10 times the dosage currently used for alcohol dependence) of high-dose oralRead More

Paru dans « Science » le 6 mai 2011

LA REVUE AMÉRICAINE « SCIENCE » CONSACRE UNE PLEINE PAGE AU LIVRE « LE DERNIER VERRE » D’OLIVIER AMEISEN AINSI QU’A SES TRAVAUX. PARU LE 6 MAI 2011, L’ARTICLE RELATE LES 6 ANS DE COMBAT D’OLIVIER AMEISEN AFIN DE FAIRE RECONNAITRE LE BACLOFÈNE DANS LE TRAITEMENT DE LA MALADIE ALCOOLIQUE. SES APPELS REPETÉS ET RESTÉSRead More

Article de « Scientific American » 03/2008

Self-Experimenters: To Purge Binges, Alcoholic Cardiologist Self-Prescribed an Experimental Drug Olivier Ameisen had tried everything to dry out then he heard about baclofen By Nikhil Swaminathan OLIVIER AMEISEN cured his own alcohol dependency by prescribing himself high doses of baclofen, a generic drug typically used to treat muscle spasms COURTESY OF OLIVIER AMEISEN This isRead More